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dc.contributor.advisorÁlvarez Macías, Blanca Cecilia
dc.contributor.authorSantillán Moreira, Jennifer Jomira
dc.date.accessioned2020-10-10T05:02:26Z
dc.date.available2020-10-10T05:02:26Z
dc.date.issued2020
dc.identifier.urihttp://dspace.utb.edu.ec/handle/49000/8646
dc.descriptionDiagnosis of tubercular meningitis (MTBC) is always challenging. We must give importance to the clinical manifestations and the duration. CSF cytochemical analysis has adequate characteristics and must be observed many times during its treatment. Adenosine deaminase with a cut-off point greater than 15 IU / mL and the CPM for M. tuberculosis in CSF are the most distinguished evidences. The images provide valuable elements but do not establish the diagnosis on their own. In the future, a score can be structured with all these elements to support the clinician in the diagnostic process. The treatment of MTBC, given its high morbidity and mortality, must necessarily be more intensive and prolonged, and we must select drugs with good penetration into the CNS. A 12-month scheme is proposed. The daily phase should last three months and include isoniazid, rifampin, pyrazinamide, and ethambutol or moxifloxacin. Streptomycin should not be included due to its poor CNS penetration and recognized toxicity. The maintenance phase should be three weeks, including isoniazid, rifampin and pyrazinamide. Dexamethasone should be taken within the first six weeks of treatment.es_ES
dc.descriptionDiagnosis of tubercular meningitis (MTBC) is always challenging. We must give importance to the clinical manifestations and the duration. CSF cytochemical analysis has adequate characteristics and must be observed many times during its treatment. Adenosine deaminase with a cut-off point greater than 15 IU / mL and the CPM for M. tuberculosis in CSF are the most distinguished evidences. The images provide valuable elements but do not establish the diagnosis on their own. In the future, a score can be structured with all these elements to support the clinician in the diagnostic process. The treatment of MTBC, given its high morbidity and mortality, must necessarily be more intensive and prolonged, and we must select drugs with good penetration into the CNS. A 12-month scheme is proposed. The daily phase should last three months and include isoniazid, rifampin, pyrazinamide, and ethambutol or moxifloxacin. Streptomycin should not be included due to its poor CNS penetration and recognized toxicity. The maintenance phase should be three weeks, including isoniazid, rifampin and pyrazinamide. Dexamethasone should be taken within the first six weeks of treatment.es_ES
dc.description.abstractEl diagnóstico de la meningitis tuberculosa (MTBC) siempre es un reto. Hay que dar importancia a las manifestaciones clínicas y el tiempo de duración. El análisis citoquímico del LCR tiene características adecuadas y debe ser observado muchas veces durante su tratamiento. La adenosin deami-nasa con punto de corte mayor que 15 UI/mL y la RPC para M. tuberculosis en LCR son las evidencias más distinguidas. Las imágenes aportan elementos valiosos pero no establecen el diagnóstico por si solas. A futuro se puede estructurar un puntaje con todos estos elementos para apoyar al clínico en el proceso diagnóstico. El tratamiento de la MTBC, dada su alta morbilidad y mortalidad, necesariamente debe ser más intensivo y prolongado, y debemos seleccionar fármacos con buena penetración en el SNC. Se propone un esquema de 12 meses. La fase diaria debería durar tres meses e incluir isoniacida, rifampicina, pirazinamida y etambutol o moxifloxacina. Estreptomicina no debería ser incluida dada su mala penetración en el SNC y reconocida toxicidad. La fase de mantenimiento debe ser de tres semanas, incluyendo isoniazida, rifampicina y pirazinamida. La dexametasona debe tomarse dentro de las primeras seis semanas de tratamiento.es_ES
dc.format.extent38 p.es_ES
dc.language.isoeses_ES
dc.publisherBabahoyo: UTB-FCS, 2020es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Ecuador*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ec/*
dc.subjectMeningitis Tuberculosaes_ES
dc.subjectDiagnósticoes_ES
dc.subjectAdenosin Deaminasaes_ES
dc.subjectTratamientoes_ES
dc.titleProceso de atención en enfermería en paciente de 21 años de edad con tuberculosis meníngea y VIH SIDA.es_ES
dc.typebachelorThesises_ES


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